Oocyte vitrification for fertility preservation for both medical and nonmedical reasons

Growing evidence of successful outcomes achieved with the oocyte vitrification technique has greatly contributed to its application in field fertility preservation (FP). The population that can benefit from FP includes women at a risk losing their ovarian function because either iatrogenic causes or natural depletion reserve. Therefore, oncological patients and healthy who wish delay motherhood for various reasons—elective FP—are currently being offered this option. Satisfactory survival rates clinical outcomes, including cumulative live birth rates, have been reported recent years. These studies show age retrieval strongly affects reproductive prognosis after FP. elective should be encouraged decide before they reach 35 years significantly increase chances success. effect also observed cancer diagnosed endometriosis. outcome is worse cancer, but direct association between disease yet proven. Young (?35 years) endometriosis undergone cystectomy than nonoperated age-matched groups. In addition, number oocytes used per patient closely related success all populations, considerable improvement result addition few oocytes, especially young patients. Discuss: You discuss article authors other readers https://www.fertstertdialog.com/posts/32145 purpose (FP) preserve both male female gametes individuals whose threatened by reasons. Cryopreservation gamete occurred during second half 2000s, concomitantly upsurge escalation efficient vitrification. Nevertheless, history cryopreservation fraught failures, beginning publication first via slow freezing 1986 (1Chen C. Pregnancy human cryopreservation.Lancet. 1986; 1: 884-886Abstract PubMed Scopus (793) Google Scholar), followed practically no reports results subsequent continuous efforts. This negative trend began change emergence Thus, baby born using technology was 1999 (2Kuleshova L. Gianaroli Magli Ferraretti A. Trounson Birth following small oocytes: case report.Hum Reprod. 1999; 14: 3077-3079Crossref (425) Scholar). Nonetheless, existing protocols still had improved, it later when publications consistent started appear (3Cobo Diaz Clinical vitrification: systematic review meta-analysis randomized controlled trials.Fertil Steril. 2011; 96: 277-285Abstract Full Text PDF (297) Scholar) as consequence more refined (4Kuwayama M. Highly embryos: cryotop method.Theriogenology. 2007; 67: 73-80Crossref (602) use vitrified ovum donation (5Cobo Meseguer Remohi J. Pellicer Use cryo-banked an programme: prospective, randomized, controlled, trial.Hum 2010; 25: 2239-2246Crossref (401) Scholar, 6Cobo Garrido N. Six years' experience report impact storage time, development predictive model rate.Fertil 2015; 104: 1426-1434.e8Abstract (105) egg banking, which might soon go beyond programs applied indications. Available safety technique, confirmed lack adverse obstetric perinatal vitro fertilization (IVF) cycles advancement approach (7Cobo Serra V. Olmo I. Obstetric babies oocytes.Fertil 2014; 102: 1006-1015.e4Abstract (142) 8Noyes Porcu E. Borini Over 900 apparent congenital anomalies.Reprod Biomed Online. 2009; 18: 769-776Abstract (364) 9Setti P.E. Albani Morenghi Morreale G. Delle Piane Scaravelli et al.Comparative analysis fetal neonatal pregnancies fresh cryopreserved/thawed same group patients.Fertil 2013; 100: 396-401Abstract (30) As result, different situations assisted reproduction (AR). context, build larger cohorts poor responders (6Cobo 10Greco Litwicka K. Arrivi Varricchio M.T. Zavaglia D. Mencacci al.Accumulation modified improve IVF results: pilot study.J Assist Reprod Genet. 30: 1465-1470Crossref (6) help euploid blastocysts preimplantation genetic testing aneuploidy (11Milan Cobo A.C. Rodrigo Mateu Mercader Buendia P. al.Redefining advanced maternal indication screening.Reprod 21: 649-657Abstract (42) 12Chamayou S. Sicali Alecci Ragolia Liprino Nibali al.The accumulation strategy available transfer testing.J 2017; 34: 479-486Crossref (20) embryos useful embryo recommended high hyperstimulation syndrome (13Herrero Pareja Losada Garcia-Velasco J.A. Avoiding chorionic gonadotropin combined GnRH agonist triggering versus coasting: new avoid syndrome.Fertil 95: 1137-1140Abstract (47) Egg banking autologous inseminate limited legal restrictions (14Levi-Setti Patrizio Bolli Vigiliano De Luca R. al.ART frozen data Italian ART registry (2005–2013).J 2016; 33: 123-128Crossref (27) even personal choices. helps solve unexpected partner’s semen sample not available. 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Fertility endometriosis.Front Biosci (Elite Ed.). 2012; 4: 1654-1662Crossref known compromise function, why associated infertility scenarios, conception, intrauterine insemination, (18Tomassetti D'Hooghe T. Endometriosis infertility: insights into causal link management strategies.Best Pract Res Clin Obstet Gynaecol. 51: 25-33Crossref (48) chronic systemic inflammatory process predisposition anatomic, tubal, ovulatory changes; present up 50% infertile couples (19Gupta Goldberg J.M. Aziz Krajcir Agarwal Pathogenic mechanisms endometriosis-associated infertility.Fertil 2008; 90: 247-257Abstract (267) proposed counteract endometriosis-related safeguarding vitrifying (20Somigliana Vigano Filippi F. Papaleo Benaglia Candiani al.Fertility endometriosis: all, some, none?.Hum 1280-1286Crossref (63) Furthermore, endometrioma frequently need repetitive conservative surgery ovaries, lead premature failure diminishing reserve, which, turn, pregnancy reduced almost primary (21Garcia-Velasco Somigliana Management endometriomas requiring IVF: touch touch.Hum 24: 496-501Crossref (203) perfect Another relevant branch (EFP) postpone parenthood. alternative represents step forward AR one contributions medicine Because role EFP modern society, compared effect, back days, appearance contraceptive pill. An increasing societies delaying childbearing age. partner common reasons choosing (22Inhorn M.C. Birenbaum-Carmeli Birger Westphal L.M. Doyle Gleicher al.Elective underlying socio-demography: binational global implications.Reprod Biol Endocrinol. 16: 70Crossref (46) Additionally, aids women’s emancipation giving them chance focus on career goals life apart motherhood, providing opportunity become pregnant future, whenever wish, own (23Homburg van der Veen Silber S.J. Oocyte vitrification—women's set stone.Fertil 91: 1319-1320Abstract (77) current helpful clarifying efficiency and, therefore, true (24Cobo Coello preservation.Fertil 105: 755-764.e8Abstract (290) focuses endometriosis, electively EFP, special main factors populations. there 25Rienzi Gracia Maggiulli LaBarbera A.R. Kaser D.J. Ubaldi F.M. al.Oocyte, blastocyst ART: comparing slow-freezing produce guidance.Hum Update. 23: 139-155PubMed proportion least informed remains small. Currently, literature offers little opt (onco-FP). may decides very large though slightly over 10 fact, study published 2018 showed procedures within Instituto Valenciano de Infertilidad network, 2% were performed context onco-FP (26Cobo Elective onco-fertility preservation: outcomes.Hum 2222-2231Crossref (114) Likewise, returning low. publication, best our knowledge, largest date onco-FP, return rate 7.2% documented 2007 method (27Yang Brown S.E. Nguyen Reddy Brubaker Winslow K.L. Live developed cryopreserved harvested treatment.Fertil 87: 1469.e1-1469.e4Abstract (86) A woman Hodgkin lymphoma chemotherapy. year later, twins ovariectomized borderline (28Porcu Venturoli Damiano Ciotti P.M. 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Schildauer Brannstrom reasons: 6-year utilization Swedish center.Acta Gynecol Scand. 98: 1429-1434Crossref (14) 42Cobo Giles Paolelli observational 2020; 113: 836-844Abstract (43) case, Europe, atypical medullar Subsequent grafting tissue, 16 4 stimulation cycles. gave twins. introduced early 2000s employed methods routine practice. al. (33Kim 9 storage. electron microscope grids vitrification, longer practice technical difficulties involved.Table 1Oocyte populations.AuthorIndicationNo. patientsNo. cyclesNo. warmed oocytesSurvival (%)Clinical (%)Live (%)Sanchez-Serrano al., 2010 Scholar)?Onco-FP119100100100Kim 2011 Scholar)Onco-FP11771.4100100García-Velasco 2013 (34Garcia-Velasco Scholar)?Onco-FP1142525EFP262619184.842.319.2Alvarez 2014 (35Alvarez Scholar)Onco-FP11887.5100100Da (36da Scholar)Onco-FP12195050Martinez (37Martinez Scholar)Onco-FP11116592.354.5Perrin 2016 (38Perrin Scholar)Onco-FP115100100100Cobo Scholar)?EFP1371481,18285.246.220.9Doyle (39Doyle Scholar)EFP1281,28386.157.138.6Specchia 2019 (40Specchia Scholar)Onco-FP11147386.330.815.4Diaz-Garcia Scholar)?Onco-FP4977.336.429.1Cobo Scholar)?EFP6416805,83083.950.733.7Onco-FP808160581.841.431Wennberg (41Wennberg Scholar)EFP38493937826.3Cobo 2020 (42Cobo Scholar)?Endo-FP4855294,53183.245.946.4Note: Totals calculated marked asterisks (?) belong investigators; overlapping. = preservation; endo-FP endometriosis; preservation. Open table tab Note: 2013, another returned t